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The 2013 Journal of Neurochemistry paper by McCoy et al

Recent experimental studies further suggest that -synuclein pathology might begin in the periphery, and the pathological form of the protein may be transferred via the vagal nerve by retrograde transport from the gut wall to the dorsal nucleus of the vagus in the brain, which was originally hypothesized by Braak et al

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Some patients notice initial improvements in mental clarity, focus, or learning capacity within 1-2 weeks as synaptic formation begins

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