The complex nature of HLA class II alleles in MS, including allelic heterogeneity and gene-environment interactions, suggests that cobalamin deficiency may be influenced by multiple genetic and environmental factors [156]
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Bo qun: Bo qun ni kh ro, thong mt, trnh xa tm tay tr em
Abnormalities of Homocysteine Metabolism Dysfunctions related to congenital defects in enzymes involved in homocysteine metabolism, to deficiencies in the supply, absorption, or metabolism of folates, vitamins B 12 and B 6 , and to dietary methionine excess all contribute to increasing plasma homocysteine levels (Table 1)
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