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Bryant et al (1996) have used site-directed mutagenesis to construct pepsin-resistant muteins of an IGF-1 analogue, long-R3-IGF-1

This is thought to be linked with the changes in the way the nerves function during vitamin b12 deficiency

[ In general, it is considered that serum UA values between 3.5 and 7.2 mg/dL (0.210.43 mmol/L) in adult males and postmenopausal women and between 2.6 and 6.0 mg/dL (0.16-0.36 mmol/L) in premenopausal women are normal in many countries

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