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Active Ingredient : Semaglutide, a GLP-1 receptor agonist Mechanism of Action : According to FDA prescribing information, semaglutide works by: Increasing glucose-dependent insulin secretion Decreasing glucagon secretion Slowing gastric emptying Acting on centers in the brain that regulate appetite Clinical Trial Evidence - STEP Program : According to published data from the STEP 1 trial (New England Journal of Medicine, 2021): Study Design : 68-week randomized, double-blind, placebo-controlled trial 1,961 adults without diabetes Inclusion: BMI 30 or 27 with weight-related conditions Intervention: Once-weekly subcutaneous semaglutide 2.4 mg Lifestyle: 500-calorie deficit diet plus 150 minutes/week physical activity Primary Results : Semaglutide group: Average 14.9% body weight loss (approximately 33 lbs for 220 lb individual) Placebo group: Average 2.4% body weight loss (approximately 5 lbs for 220 lb individual) Difference: 12.4 percentage points (p 3 pounds/week associated with higher risk
In SURPASS trials, it produced dose-dependent HbA1c reductions and weight loss consistently exceeding those of semaglutide
Clinically proven to increase GLP-1 production by 140% on average, the two-product system is making new strides in health and wellness
Jacob Sheskin discovered its unexpected benefits in treating painful leprosy complications
Prescription medication is provided only when an independent licensed clinician determines that it is appropriate
Semaglutide is also available in a pill form under the brand name Rybelsus
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