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The 12mg weekly arm produced a 24.2% mean body weight reduction over 48 weeks, with 26% of participants achieving at least 30% total body weight loss a threshold previously unattained by any pharmacological intervention in a clinical trial setting

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Probiotics may help by supporting gut microbiome stability during the adjustment period

The appetite suppression deserves special attention

[5] Clinicians and patients should rely on trial-specific protocols and peer-reviewed literature for evidence-based decision-making

Regular aerobic exercise improves cerebral blood flow, promotes neuroplasticity, reduces inflammation, and enhances mood