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Methylcobalamin, also known as Methyl B12, is a naturally occurring form of vitamin B12 that can also be found in foods like fish, meat, eggs, and milk

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112113, 357363 10.1016/S0378-4274(99)00230-1 [DOI] [PubMed] [Google Scholar] Sullivan D

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Vitamin C T strong evidence (photoprotection, collagen, antioxidant) O supports systemic antioxidant network & glutathione recycling T + O Vitamin E (-tocopherol) T synergistic with Vit C, lipid membrane protection O systemic antioxidant, supports skin barrier T + O Vitamin A (retinoids / carotenoids) T gold standard for skin ageing (retinoic acid, retinal) O via carotenoids (not retinoic acid directly) T + O (different biological roles) Flavonoids (polyphenols) T limited but supportive (surface antioxidant/anti-inflammatory) O primary effective route O (primary) + T (adjunct) Resveratrol T antioxidant, anti-inflammatory (stability dependent) O poor bioavailability but systemic signalling effects T + O (modest evidence) Green tea catechins (EGCG) T good evidence (UV protection, anti-inflammatory) O strong systemic antioxidant & anti-inflammatory effects T + O -Carotene T minimal benefit O primary effective route (photoprotection over time) O only Lycopene T negligible penetration O strong evidence for systemic & skin photoprotection O only Lutein T emerging but limited evidence O primary route (skin & eye antioxidant) O (primary) T (adjunct) Zinc T anti-inflammatory, barrier support O enzyme function, immune & antioxidant roles T + O Selenium T no meaningful evidence O essential for glutathione peroxidase O only Copper T minimal relevance O essential trace element (SOD, collagen cross-linking) O Only Topical antioxidants primarily protect against environmental oxidative stress, whereas oral antioxidants support intracellular endogenous antioxidant systems. Clinical Application in Aesthetic Practice Antioxidants support healing after procedures (lasers, microneedling, chemical peels)

Glucagon-like peptide-1 (GLP-1) receptor agonistsincluding semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), and liraglutide (Victoza, Saxenda)along with tirzepatide (Mounjaro, Zepbound), a dual GIP/GLP-1 receptor agonist, have transformed the management of type 2 diabetes and obesity