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Data sources Orforglipron ATTAIN-1 trial: Eli Lilly press release (August 2025) Tirzepatide SURMOUNT-1 trial: Eli Lilly published data Indirect comparison metaanalysis: Circulation (2024) GI adverse events metaanalyses: Endocrinology, Diabetes & Metabolism (2024) and Diabetes, Obesity and Metabolism (2023)

Health Benefits Consumption of Berberine is often associated with many health benefits, and some of them are: Cholesterol management Weight Management Improving gut health Anti-inflammatory and antioxidant Antimicrobial Improve cardiac health 3

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The best medication depends on your medical history, weight loss goals, current health, and lifestyle

This is true for the tissue-restorative microglia (M2) phenotype as opposed to the M1 phenotype

Am J Hypertens (2004) 17:100510