Neurological symptoms such as paraesthesia, balance problems, or cognitive difficulties typically take 36 months to improve and may continue improving for up to 1218 months
Arthritis Res Ther (2016) 18(1):287
Nat Rev Mol Cell Biol
While there's no official upper limit, doses up to 2,000 mcg can be safely used to treat B12 deficiency under medical supervision
Originally developed to study metabolic disorders and insulin resistance , 5-Amino-1MQ has now gained attention in fitness and longevity circles for its ability to: Reduce fat cell size Increase NAD levels (critical for energy and mitochondrial function) Enhance insulin sensitivity and metabolic efficiency When NNMT is overactive as is often the case with obesity, aging, and chronic disease it limits the availability of nicotinamide and reduces NAD production
Strict vegetarians and vegans are also at a higher risk of developing a B12 deficiency than lacto-ovo vegetarians (vegetarians who still eat eggs and dairy products) and non-vegetarians, according to the NIH
