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Therefore, PPAR-associated ferroptosis in DCs hinders anti-tumor immunity in mice, which suggests that ferroptotic DCs possess a novel function in fostering an immunosuppressive TME

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Shimizu N, Watanabe T, Arakawa T, et al

Following transfection, cells were incubated for 12 h, after which 1 mM sodium butyrate was added, and incubation continued for an additional 48 h