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1,4 About POMC, PCSK1, and LEPR deficiencies Rare autosomal recessive disorders 2 Lead to hyperphagia and early-onset, severe obesity, mainly due to genetic variants in the MCR4 pathway 2 Can be difficult to diagnose based solely on clinical manifestations, so genetic testing is required to confirm a diagnosis 1,5 Learn if IMCIVREE may be appropriate for your patients with POMC, PCSK1, or LEPR deficiency

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The PlexusDx Precision Peptide Genetic Test examines variants like GLP1R rs6923761 and MC4R rs17782313 that influence how efficiently your body utilizes amino acids and responds to appetite suppression