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In the UK and many European countries, national health authorities evaluate cost-effectiveness before approving medications for public healthcare coverage

For example, a patient with type 2 diabetes on GLP-1 scheduled for hip replacement may continue the agent until 1 to 2 weeks pre-op if weight loss is modest, but stop earlier if gastroparesis or severe nausea is present

This is a catastrophic waste of time and resources

I started exercising with a personal trainer and realized how strong I was

The key is keeping the toppings light so it doesn't get heavy

However, emerging drugs that target the main autoantigen (monoclonal antibodies, small molecules, peptides) or block the immune pathway have been recently tested in clinical trials