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Individuals with severe gastrointestinal problems such as gastroparesis (delayed stomach emptying) or a history of severe pancreatitis (inflammation of the pancreas) should not use tirzepatide, as it can aggravate these conditions

This highlights the need for more rigorous research to fully understand the potential benefits and to explore the inclusion of treatments like low FODMAP probiotic and prebiotic in these studies

Further studies are needed to confirm that the effect is dose dependent or not

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[24] However, the study also highlighted that results varied, and further research is needed to better understand berberines role in weight management

For example, if you were taking medication daily, switching to weekly medication may be challenging, as you may forget to administer your next dosage on the scheduled day due to the gap of one week