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Of note, activation of ENaC causes depolarization of the membrane potential and induces activation of voltage-dependent calcium channels (VDCC) [37, 38]

Notably, BIX-01294 and the antioxidant control butylated hydroxyanisole (BHA) similarly decreased ROS/RNS levels

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The findings of no increased heart rate in the setting of BP reduction may be interpreted as a result of relative reduction in the sympathetic nervous system tone, although modulation of other neurohormonal factors also could play a role (56)