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In another study, the CSF level of HVA could not differentiate PD patients from the controls, but the ratio of xanthine/HVA clearly separated the two groups (LeWitt et al., 2011)

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because B vitamins are essential for a wide range of functions in the body

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Table 1 summarized the clinical trials of metformin and TZDs on cognition, MCI, AD, and PD