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Evaluation at 12 weeks: If a patient has not lost at least 3% of body weight by week 12 on the 7.5/46 mg dose, the prescriber will either titrate up to 11.25/69 mg for 14 days then 15/92 mg, or discontinue the medication entirely

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Within 30 minutes of waking: one serving of electrolyte drink mix in 16oz of water

10.1007/s00018-009-0145-9 6 BaileyD