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We included peer-reviewed articles written in English that investigated the impact of GLP-1 RAs on bone health, bone metabolism, or bone remodeling in human subjects or relevant animal models

For those with preserved ejection fraction (HFpEF), GLP-1 medications reduced the composite of cardiovascular death or worsening heart failure events by 32% 15

J Clin Invest (2013) 123(6):27306

Lu J et al

5 A major component of this detrimental effect is thought to originate from obesity-diabetes induced changes in the secretion and biological action of gut-derived peptide hormones

Uncovering CNS access of lipidated exendin-4 analogues by quantitative whole-brain 3D light sheet imaging