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Conditions such as pernicious anaemia, gastrointestinal surgery, or inflammatory bowel disease impair B12 absorption in the terminal ileum

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Comparative risk of anemia and related micronutrient deficiencies after Roux-en-Y gastric bypass and sleeve gastrectomy

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When B12 injections are obtained outside regulated healthcare settingssuch as from wellness clinics or online providersadditional risks emerge

observed in Nature Medicine , NNMT inhibition in adipose tissue produced favorable body composition changes without negatively impacting muscle mass (Kraus et al., Nature Medicine )