This reduces the chance of temperature shock and helps the powder dissolve more evenly
Cell Death & Disease , 11 (2), 102 Yu, Y., Cen, C., Shao, Z., Wang, C., Wang, Y., Miao, Z., Sun, M., Wang, C., Xu, Q., Liang, K., Zhou, J., Zhou, D., Ji, H., Xu, G., & Du, Y
New-onset diabetes mellitus, hypertension, dyslipidaemia as sequelae of COVID-19 infection-systematic review

Reduced glomerular filtration or kidney reserve Dehydration or inconsistent fluid intake Low bicarbonate or limited buffering capacity High dietary acid load with low vegetable intake Sleep apnea or impaired nighttime oxygenation Sedentary lifestyle and low aerobic conditioning Gut fermentation and dysbiosis Alcohol, diuretics, stimulants and selected medications Elevated SAH and low SAM:SAH ratio Elevated homocysteine Low serum carbon dioxide or bicarbonate Creatinine, cystatin C and estimated GFR Urinalysis and urine albumin Uric acid, electrolytes and phosphorus Adenosine and expanded methylation analytes when available The clinical question is not simply Is the patient acidic? The more useful question is whether filtration, hydration, buffering, enzyme efficiency and downstream disposal are adequate to keep SAH, homocysteine, adenosine and other metabolites moving through the pathway

Cross talk between eIF2alpha and eEF2 phosphorylation pathways optimizes translational arrest in response to oxidative
It is sensible to keep the dosage level on a slightly higher side to cater for the rate of absorption by the human body