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Pregnancy registries and post-marketing surveillance have documented cases where women became pregnant whilst taking these medications, but numbers remain too small to draw definitive conclusions about safety
These findings add to a growing body of evidence suggesting that GLP-1 receptor agonists provide vascular benefits across multiple organ systems
This results in a higher predicted receptor occupancy for GIPR (40%) than for GLP-1R (10%) at therapeutic concentrations
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These include personal or family history of medullary thyroid cancer, multiple endocrine neoplasia syndrome, or severe gastrointestinal conditions
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