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The SURMOUNT-1 trial showed participants losing up to 22.5% of their body weight on the highest dose, compared to approximately 15-17% with semaglutide in the STEP trials
A post hoc analysis of the SURMOUNT-5 study found that tirzepatide was associated with a greater predicted 10-year cardiovascular disease risk reduction compared to semaglutide
A., Heekin, K., Mutchie, H
Glucagon receptor activation is what sets Retatrutide apart from other medications
In the first half of 2025, Mounjaro sales alone approached several billion dollars, putting it on track to challenge Novos Wegovy/Ozempic for the highest sales in the weight loss/diabetes class