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When patients on these therapies develop yeast infections, it is more likely attributable to underlying diabetes, other medications (particularly SGLT2 inhibitors if used concomitantly), antibiotic use, or individual risk factors rather than the incretin-based agent itself
If the vial has an unknown history, treat it as unreliable
What side effects should I expect in the first week
For expensive drugs such as glucagon-like peptide 1 receptor agonists (GLP-1s), payer coverage is crucial for patient affordability
For instance, MCT1 inhibition in glycolytic tumors induces a metabolic catastrophe that triggers caspase-dependent apoptosis alongside GSH depletion-mediated ferroptosis, thereby yielding enhanced antitumor efficacy relative to the activation of either pathway alone (142)
All FDA-approved GLP-1 and GIP/GLP-1 agonists carry a boxed warning for thyroid C-cell tumor risk seen in rodent studies, and rarer serious events include pancreatitis, gallbladder disease, and dehydration-related acute kidney injury
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