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It contains a thiamine diphosphate cofactor and catalyzes thiamine diphosphate dependant decarboxylation of 2 oxoglutarate and subsequent reductive acylation of the oxidized lipoyl moiety LBD (lip-LBD-S2) which is covalently bound to the E2 component dihydrolipoamide succinyl transferase [5]

In-vitro study on human fibroblasts

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Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat-diet-induced obesity in mice