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Both the LEADER (liraglutide) and SUSTAIN-6 (subcutaneous semaglutide) trials reported significant reductions in the primary outcome (incidence of MACE)

As we continue to explore the realm of GLP-1 medications, it is imperative to recognize that these treatments should be used alongside lifestyle modifications for optimal results

A phase 1 mechanistic study of people with T2D reported a mean weight change at week 28 of 11.2 kg among participants assigned to tirzepatide 15 mg as compared with 6.9 kg for semaglutide 1.0 mg and no change (0 kg) for placebo [38]

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Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action

It stimulates insulin secretion from pancreatic beta cells in a glucose-dependent manner, meaning it only promotes insulin release when blood sugar levels are elevated