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Acknowledgements We apologize to all contributors to this field of research whose work is not discussed here owing to space restrictions

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doi:10.1016/j.jad.2011.06.005 Farokhnia M, Azarkolah A, Adinehfar F, Khodaie-Ardakani MR, Hosseini SM, Yekehtaz H, Tabrizi M, Rezaei F, Salehi B, Sadeghi SM, Moghadam M, Gharibi F, Mirshafiee O, Akhondzadeh S (2013) N -acetylcysteine as an adjunct to risperidone for treatment of negative symptoms in patients with chronic schizophrenia: a randomized, double-blind, placebo-controlled study

Some people find that side effects lessen over time with dose adjustments, but not everyone tolerates the oral medication well

Inflammatory tone is lower

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