However, sperm from the head and tail of the epididymis in SNGPX4 KO mice are more prone to decline than WT mice at various stages of epididymis maturation, suggesting that SNGPX4 plays an important role in stabilizing the structural integrity of sperm chromatin (Gharagozloo et al., 2016)
10.1007/s00421-009-1110-x 227 OstrowskiK.RohdeT.AspS.SchjerlingP.PedersenB
Rush JE, Freeman LM, Brown DJ, Brewer BP, Ross JN and Markwell PJ (2000)
Ann Biomed Eng
Oxidized LDL (oxLDL) can induce further production of proteoglycans by vascular smooth muscle cells, retaining more LDL in the arterial wall
In the absence of population-specific data, clinical use should be accompanied by vigilant monitoring for class-wide effects (particularly gastrointestinal symptoms) and agent-specific concerns, with dose titration individualized to tolerability