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When expressed at the low levels representative of in vivo amounts, at least one laboratory has found that basal activity was not detectable (Kern et al., 2012)

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A favorable safety profile has been observed in term neonates, particularly during cardiopulmonary bypass (232, 233)

We speculate that this decrease in oxidative protein folding precludes excessive ROS load in the ER but at the expense of increased unfolded protein levels

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