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Retatrutide works through a triple-agonist mechanism that targets three major hormone receptors involved in appetite regulation and energy metabolism: GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon

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The FDA has recently approved generic versions of two other GLP-1 drugs, Victoza (liraglutide) and Byetta (exenatide)

Hydration levels are also very important, as thirst signals could be mistaken for hunger