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The serendipitous discovery of exendin-4 led to the development of exenatide immediate-release (exenatide IR, Byetta), a synthetic version of exendin-4 with C-terminal amidation to enhance its stability [ Figure 2 , Table 1 ], which became the first FDA-approved GLP-1RA in 2005 for the treatment of T2DM in adults [ Table 2 ]

Acetic acid water for stubborn peptides A few peptides will not fully dissolve in plain BAC water because they need a slightly acidic environment

Among the microorganisms altered by liraglutide, Lactobacillus delbrueckii was the most significantly increased species

The Case of TB-500: A Scientific 'Bait and Switch' The evidence for TB-500 is even more deceptive

Learned about folate 3-4 years ago and added that too

In humans and mice, GLP-1 is predominantly amidated, whereas in rats both amidated and nonamidated GLP-1 is present (1,2)