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36 Interestingly, commonly used cardioprotective agents, including statins and ACE inhibitors, appear to indirectly enhance mitophagy signaling, highlighting their broader mechanistic relevance

Further studies also suggest potential downstream signaling through the JAK-STAT pathway, which could influence the transcription of IGF-I

Specific CYP3A4 inhibitors like troleandomycin have been shown to inhibit AFBO production [29], while inducers of CYP3A4 activity such as 3-methylcholanthrene and rifampicin, increase AFB 1 metabolism in cultured human hepatocytes [49]

Br Med J (Clin Res Ed) 1981;282:1516

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