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For some patients, smaller divided doses may reduce nausea and digestive side effects by creating less abrupt medication peaks

10.1001/jamainternmed.2024.4369 Summary Keywords cardiovascular disease, cardiovascular outcome, glucagon-like peptide-1 receptor agonists, heart failure, obesity Citation Turkistani Y (2025) Glucagon-like peptide-1 receptor agonists: a review from a cardiovascular perspective

Overall Heart Health Bradycardia often has a connection with heart tissue damage or some type of heart disease

The most likely explanation relates to the metabolic changes these medications induce

their reduction is achieved by Trx