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Gastrointestinal symptoms (nausea, vomiting, diarrhoea) are most common, typically improving with gradual dose titration

Standard GLP-1 dosing is supported by randomized clinical trials, while microdosing has not been studied at those same levels

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Along with pro-inflammatory cytokines, synovial cellular infiltration and invasive behaviour are triggered by VEGF, which is a critical regulator of angiogenesis in RASFs under hypoxic conditions 47

Discussion This study has provided evidence regarding the utilization of GLP-1 RAs, including medications such as liraglutide and semaglutide, at various dosages within real-world settings