2 Phase I Clinical Trial Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, Peoples Republic of China
While the melanocortin 4 receptor (MC4R) has often been the target for obesity treatment, to the best of our knowledge no dimerization between GHSR1a and MC4R has been identified
*In a 68- and 72-week clinical trial studying Wegovy (2.4 mg) and Zepbound (15 mg) in patients without diabetes and with BMI 30, or BMI 27 with a weight-related condition, the average weight loss was 15% and 20%, when paired with diet and exercise changes (compared to 2.4% and 3.1%, respectively, with diet and exercise alone)
We therefore used female animals in our study
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