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Current safety data for 5-amino-1MQ appears favorable for short-term use (8-12 week cycles), with no significant toxicity observed in preclinical studies at therapeutic doses

1 , 2 The ADA/EASD consensus report also recommends the use of GLP1RAs as firstline pharmacotherapy for patients with a contraindication to metformin 2 and the American Association of Clinical Endocrinologists (AACE)/American College of Endocrinology guidelines include use of GLP1RAs as monotherapy for all patients with T2D

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These habits may require a bit more discipline than simply using GLP-1s, but they have long-established science on their side