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Semaglutide has been shown to reduce total body weight in overweight or obese patients, in both clinical trials and everyday clinical settings

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In some cases, it might actually reduce them

For sublingual formulations specifically, the oral mucosal absorption pathway avoids first-pass metabolism through the liver, which may influence how the compound behaves in the body

In the retatrutide Phase 2 trial, high-sensitivity CRP fell alongside body weight [1], which mechanistically predicts improved central androgen signaling even before peripheral hormone levels are measured