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For instance, N-Acetyl-Nle-Tyr-Ile-His had a half-life of 115 7.6 min, D-Nle-Tyr-Ile showed 225 23.7 min, and GABA-Tyr-Ile exhibited a remarkable 946 234 min

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It should be mentioned that connecting acyl and acetyl groups to LC increases LCs hydrophobicity, which facilitates LCs crossing of the bloodbrain barrier

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This pattern of Delta sleep inducing peptide is particularly influential during slow-wave sleep (SWS) and rapid eye movement (REM) sleep, the phases when we dream and rejuvenate our minds (Kastin & Akerstrom, 2003)