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Kidney function markers such as creatinine and eGFR remain stable in most patients, though your doctor will monitor these at baseline and periodically during therapy

These are macroscopic indicators of advanced degradation

A small randomized controlled trial ( N = 40) showed that 6-month dapagliflozin treatment was associated with a significant reduction in EAT volume compared to baseline, with no changes in the control group [43]

The largest differences in active structures relative to the inactive GCGR occur in TM1, TM6, TM7 and ECL3 ( h ), but the nature and extent of conformational change varies

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