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Preclinical investigations have yielded significant understanding of the processes and thresholds of lipid peroxidation in cancer treatment, with agents such as sorafenib and RSL3 demonstrating effectiveness in preclinical models of therapy-resistant malignancies [240]

CEMIP, identified as an oncogene, enhances the stability and nuclear accumulation of c-Myc by inhibiting the ubiquitination of this proto-oncogene

Repeated activation of the receptors can lead to upregulation and sensitization, causing hyperexcitability of the receptor even at low levels

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