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Specifically, cryostress increases plasma membrane permeability, which in turn promotes excessive generation of reactive oxygen species (ROS) and exacerbates lipid peroxidation (LPO)

Using cancer-specific reactive metabolites to activate prodrugs presents a compelling strategy that may enable targeted accumulation of MGDs in disease tissues and could further expand the therapeutic index enabled by tissue-specific ubiquitin ligase expression

Diabetes Care (2015) 38(7):126373.10.2337/dc14-1984 56 HinshawLSchiavonMDadlaniVMalladADalla ManCBharuchaAet alEffect of pramlintide on postprandial glucose fluxes in type 1 diabetes

A warm or flushing sensation near the injection area

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Dosing, reconstitution, and injection instructions should come only from licensed health care sources.