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The peroxisome proliferatoractivated receptor coactivator 1 (PGC1) is a major regulator of mitochondrial biology through at least 2 splice variants (5): the canonical longer PGC1 isoform 1 regulates mitochondrial biogenesis and function, whereas the shorter PGC1 isoform 4 (6) increases muscle mass and strength in cachectic muscle (7) and sarcopenia (8)

Respondents utility by EQ-5D-5L was calculated by applying the established Japanese EQ-5D-5L value set

Was the outcome mean lifespan or maximum lifespan

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