The project has focused on the main cellular targets of metabolic disruption: Peroxisome proliferator activated receptor (PPAR) test methods, hepatocytes, pancreatic endocrine cells, myocytes and adipocytes-and using a mechanistic and mode of action or adverse outcome pathway (AOP) type framework, has generated key information on MDC-related modes of action ( in vitro test method development and validation, careful and relevant chemical selection needs to be conducted for each endpoint, and with clear understanding of the test methods, including their potential limitations
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Sermorelin is a growth hormone-releasing hormone analog
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found that efficacy was consistent across mRNA, DNA, viral vectors, and inactive viruses and that differences in trial design, population characteristics and other factors were stronger contributors to heterogeneity than vaccine modality
