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Patients with established type 2 diabetes treated with one to three oral antidiabetic drugs (OADs) Studies involving patients with established type 2 diabetes who were already receiving one to three OADs showed that both oral and injection semaglutide were effective in reducing HbA1c levels

Octet BLI assays To quantify interactions between the degrader-bound neosubstrates and the CTLH E3 neosubstrate receptor module, we determined the K D using Octet BLI