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Specifically, the animals displayed a strong, palatability-driven negative anticipatory effect in S1: food consumption strongly decreased in anticipation of the more palatable S2 meal, compared to when the less palatable meal was offered in S2

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In vivo experiments confirmed that the MPO/HOCl signaling pathway was significantly activated in the plasma and neurons of SOD1 G93A transgenic mice, which upregulated Caspase-3 expression, downregulated GPX4 and NQO1 expression, significantly elevated plasma MDA levels, promoted neuronal apoptosis, ferroptosis, and lipid peroxidation, and reduced motor performance in mice (Peng et al., 2022)

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As a result, supplementation of L-citrulline has generated interest in the exercise/sports nutrition arena based on its ability to produce ergogenic responses, particularly during acute, single-bout exercise scenarios

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These peptides are often used in sports medicine and by individuals recovering from chronic pain or injury

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