They are not regulated by the same safety standards that govern medications intended for patient care
it accounts for roughly 30% of tirzepatide's weight loss advantage over semaglutide in the SURMOUNT-1 vs STEP 1 comparison (Jastreboff et al., NEJM 2022
If you do choose to stop, weight regain begins within weeks
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Estrogen normally helps keep blood vessels flexible, so when levels fall, vessels can become stiffer, making them more prone to damage
