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When tirzepatide activates these receptors, it directly modulates neural circuits involved in how alert or tired you feel

Glutathione helps detoxify these substances, clearing them from your brain and preventing them from interfering with healthy brain function

Nat Genet (1998) 19(2):1557

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This can happen with semaglutide and tirzepatide, including Ozempic, Wegovy, Mounjaro, and Zepbound, even when you are using the medication correctly