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Methyl-b12 is the best absorbed version of b12 and can assist in those with anemia, brain fog, fatigue, and diabetic neuropathy

Consoli U, Priebe W, Ling YH, Mahadevia R, Perez-Soler R, Andreeff M: Annamycin, a novel anthracycline, is not affected by p-glycoprotein-related mdr: Comparison with Doxorubicin and Idarubicin

it didnt include a comparison group, and participants and researchers all knew that everyone received liraglutide

That's expected, not a sign something is wrong

This isn't just sterile water

Some small molecule TrkB agonists like LMDS-1 and LMDS-2 have shown BBB permeability in parallel artificial membrane permeability assays (Chiu et al., 2022)