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However, the statistical significance found in some studies suggests a potential association that merits further investigation. Recommendations for Patients and Healthcare Providers Given the current evidence, patients and healthcare providers should take the following steps: Monitor for Symptoms : Patients using GLP-1 RAs should be aware of potential ear-related symptoms, such as hearing loss, tinnitus, vertigo, or aural fullness

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The microbiota can uncouple the sulfated glucuronide derivatives of iodothyronine via bacterial sulfate esterase or -glucuronidase to improve the reabsorption of thyroid hormone in enterohepatic circulation [26, 138]

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Additionally, the vital protein-bound fats have been removed