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Injections are given either intramuscularly (typically in the glute or thigh) or subcutaneously (into belly fat)

This regimen should be followed by 100 mcg monthly for life

Studies that used 1 mg/day in oral and intravenous trials did not show meaningfully better outcomes than lower doses, and higher doses were associated with more reports of headache, diarrhea, and gastrointestinal effects

Archer MD, Haley CD (eds.)

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Extreme restriction is unnecessary and often counterproductive, causing metabolic slowdown that persists beyond the protocol