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Metformin reduces the glucose your liver releases and improves insulin sensitivity, while the GLP-1 drug stimulates glucose-dependent insulin release, slows gastric emptying, and dampens appetite

This reduction in estradiol and its insulin sensitizing effects could potentially decrease food intake and body weight in some women (67)

It signals your pancreas to release insulin, which helps lower your blood sugar, and it also slows down the speed at which food leaves your stomach

72, 73 A proliferative effect by GLP-1 agonists has also been reported in mouse skin cells and the pancreatic acinar cell line, AR42J

However, some controversy prevails on the optimal dose

It decreases your appetite and allows you to turn your attention away from food as your meal moves along your digestive tract