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Chronic dosing studies also support a wide margin

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In one study, chronic treatment with a low dose of clozapine (0.5 mg/kg) increased the number of bromodeoxyuridine (BrdU)-positive cells in the dentate gyrus 24 hours after BrdU administration, whereas haloperidol (0.05 or 2 mg/kg) or a high dose of clozapine (20 mg/kg) had no significant effect.134 Interestingly, the increased BrdU-positive cells with a low dose of clozapine could not survive or integrate into existing hippocampal circuitry

To reach this point, the field needs better transformation protocols, more genome and transcriptome resources focused on biotic stress, and multi-site evaluations to confirm that edited traits remain stable in real production environments (Joshi et al., 2020

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