One consideration specific to peptide stability deserves mention
LEADER [29] and SUSTAIN-6 [30] reported a prespecified renal composite of new onset or persistent macroalbuminuria, persistent doubling of serum creatinine and eGFR 45 mL/min/1.73 m 2 , need for renal replacement therapy (RRT), and renal death
144-154 Although it is challenging to synthesize the evidence due to the range of species and formulations used, a meta-analysis of data from 20 clinical trials found treatment with probiotics, killed probiotics, or cellular parts of probiotics improved subjective sleep quality in general, but did not affect objective measures of sleep
3 Results 3.1 Study selection and characteristics The initial systematic literature search across PubMed, Embase, and the Cochrane Library yielded 1,148 records
3 Gut microbiota associated diseases The gut microbiome forms complex and dynamic interactions with most of the organs of the body, establishing multiple physiological axes such as the gut-brain, gut-lung, gut-liver, gut-cardiac axis
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